منابع مشابه
Sound Amplification in the Inner Ear It Takes TM to Tango
The demonstration that information required for the generation of neurons before glia is intrinsic to individual stem cell–derived clones poses the question of mechanism. One possibility is that there is a clock intrinsic to stem cells that determines when daughter cells will be Discussions of CNS stem cell biology often leave the specified to adopt neuronal fates and when they will impression ...
متن کاملDual contribution to amplification in the mammalian inner ear.
The inner ear achieves a wide dynamic range of responsiveness by mechanically amplifying weak sounds. The enormous mechanical gain reported for the mammalian cochlea, which exceeds a factor of 4000, poses a challenge for theory. Here we show how such a large gain can result from an interaction between amplification by low-gain hair bundles and a pressure wave: hair bundles can amplify both thei...
متن کاملShaping sound in space: the regulation of inner ear patterning.
The inner ear is one of the most morphologically elaborate tissues in vertebrates, containing a group of mechanosensitive sensory organs that mediate hearing and balance. These organs are arranged precisely in space and contain intricately patterned sensory epithelia. Here, we review recent studies of inner ear development and patterning which reveal that multiple stages of ear development - ra...
متن کاملAutoimmune Inner Ear Disease- A Clinical Viewpoint
Recent developments in medicine have given us a better insight into a group of disorders known as autoimmune diseases. In particular, advances have occurred in our understanding of the Autoimmune Inner Ear Disease (AIED). In this article, the authors review the different postulated theories in the pathogenesis of this disease. The clinical presentation, the available para-clinical diagnostic to...
متن کاملBiomechanics in the Inner Ear
The elongation and contraction of outer hair cells (OHCs) greatly contribute to the high sensitivity and frequency selectivity of the mammalian inner ear. The motility of OHCs is believed to be based on the conformational changes of the motor protein prestin in the plasma membrane of OHCs. In the present study, four lines of research on the inner ear were conducted. First, the mechanism by whic...
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ژورنال
عنوان ژورنال: Neuron
سال: 2000
ISSN: 0896-6273
DOI: 10.1016/s0896-6273(00)00078-7